Abstract: Objective To study college students' drug-using behavior and satisfaction,and to provide evidence for the guidance on proper using of medicine.Methods Using stratified random sampling method,733 college students in Qingdao,Rizhao,Weifang city of Shandong province were investigated by self-made questionnaires.Results Totally 91.1% of college students hoped to restored to health by using drug.Female college students (58.6%) choose to use more inclined to advertise and prefer to use antibiotics(60.1%),students in coastal city prefer infusion(74.3%),rural students prefer the new drugs (56.9%) and imported drugs(53.1%).The difference was statistically significant.56.3% of college students was satisfaction with the present situation of drug-using behavior.Binary classification logistic regression analysis revealed,the influence factors included self-assessment of college Students' health status and medication knowledge,satisfaction with school hospitals,doctors' interpretation of the state of the illness clarity,the preference of infusion medication,and trust doctors' prescription medication(OR=1.954,1.801,1.560,2.485,1.612,2.323,P<0.05).Conclusion The drug-using behavior of college students was influenced by many factors.Government and schools should strengthen the construction of hospital and rational drug use intervention mechanism in order to provide a good system to cultivate the trust between doctors and patients.