Abstract: Objective To compare the interventional effects of four different intervention models among medical students,and to provide reference for improving the health literacy among medical students.Methods Totally 127 freshmen from preventive medicine departmnent of Tianjin Medical University were taken as object to participate in this study.And they were randomly divided into intervention group (n =32) and peer education group (n =31),mixed intervemion group (n =31) and the control group(n =33).A six-month health intervention was offered to them,and the effects of health interventions were evaluated by using the "Medi-cal Students' Health Knowledge and Health Bbehavior" questionnaire.Results After the intervention,the total scores of health were of statistically significant differences in the four groups(F=9.350,P<0.01),total score of the mixed group was the highest,higher than those of other 3 groups.Health knowledge scores of three intervention groups were increased(P<0.05),only the health behavior score of mixed intervention group was higher than that before(t =3.703,P<0.01).The interventional scores on diet and nutrition(F=13.83,P<0.01),habits(F=11.72,P<0.01),intentional/unintentional injury (F=9.050,P<0.01) were higher than those of the control groups'.The mixed group has got the highest score in these items.Conclusion Promoting students' health motivation to combine with the health needs of different grades is an efficient method to promote the students' health literacy.