Abstract: Objective To explore the relationship between adverse experiences during different period with depressive symptoms among college students,to provide basis for depression prevention.Methods A stratified cluster sampling method was used to select undergraduates from six universities in Hubei province.Data was collected through online survey.General information,family background,adverse experiences during different period and diagnosis of depressive disorder was reported by participants.Chi-square and multivariate logistic regression was used.Results Totally 5 913 eligible questionnaire were analyzed.About 82(1.4%) of the students reported depressive disorder diagnosis.Approximately 2 198(37.2%) of students reported adverse experiences during childhood,1 757(29.7%) reported adverse experiences during adolescence,and 5 158(87.2%) reported frustrating experiences during college.Among them,1 329(22.5%) reported adverse experiences both in childhood and adolescence,and 1 160(19.6%) reported adverse experiences in all three periods.Adverse childhood experiences were positively related with depressive disorder diagnosis (OR=2.351,95%CI=1.475-3.747).Adverse adolescence experiences,frustrating experiences in college and adverse experiences in two or more periods had no relation with depressive disorder(P>0.05).Conclusion More attention should be paid among college students who had adverse childhood experiences,including psychological counseling and social support,to effectively prevent depressive symptoms and depressive disorder.