Abstract: Objective To analyze the awareness of home-based quarantine knowledge among parents of chicken pox students in Panyu District of Guangzhou,and to provide evidence for chicken pox prevention and control.Methods Using stratified cluster random sampling method,2 407 patients with chicken pox reported to the Chinese Disease Control and Prevention Information System from Panyu District were selected.Telephone interviews were carried out.Results In general,796 cases aged 3-16 years old were isolated at home with varicella acquisition.Respondent rate among parents of patients was 82.04%.About 95.35% of the patients received home quarantine treatment;Awareness rate on "patients with chicken pox should receive home quarantine" was 89.07%,and the percentage of parents who knew the home quarantine should be between 15 and 21 days was 20.23%.There were significant differences among parents of children in nursery and kindergarten group,primary and middle school regarding the awareness of rehabilitation certificates for school return (P<0.05);75.13% of the respondents primarily received home-based quarantine knowledge from doctors;87.69% of the respondents knew that home-based quarantine could effectively prevent the spread of varicelia disease;52.64% of the patients reported having been outside during the isolation,among them 79.71% for further consultation.There were significant differences in proportion of patients who have been outside for academic reasons in different school stages(P