Abstract: Objective To compare awareness of smoking related-knowledge between Chinese and Pakistani college students for providing tobacco control strategy among young people.Methods Totally 1 200 undergraduates were sampled with cluster sampling method from Yangtze University in Hubei province,and investigated with self-administered questionnaire.Binary logistic regression analysis was applied to explore associated factors of smoking behavior.Results In China and Pakistan,smoking rate of male students (34.94%,32.35%,respectively) was significantly higher than female students (4.74%,0,respectively).Second hand smoking rate among male students (54.21%,35.29%) was also significantly higher than female students (45.7%,27.03%).Second hand smoking rates among Chinese college student was higher than Pakistani student.The most common place of second hand smoking was indoor public place.The awareness rate of smoking and tobacco relevant knowledge was higher in Chinese college students than Pakistani students (x2 =111.19,P < 0.05).Drinking (OR =4.273),surfing (OR =2.593),having female smoking in the family (OR=4.797) and friends support smoking (OR=3.765) were risk factors for smoking,female (OR=0.207) is protective factor for smoking among Chinese college students.High awareness rate of smoking and tobacco relevant related knowledge (OR =0.668) was protective factor,drinking (OR =11.842),roommate smoking (OR =5.303),teacher smoking (OR =6.771) were risk factors in smoking Pakistani college students.Conclusion Smoking and second hand smoking among college students is common.Health education on tobacco use should be promoted among college students.